Microglia are resident immune cells in the central nervous system CNS that are capable of carrying out prominent and various functions during development and adulthood under both homeostatic and disease conditions. Although microglia are traditionally thought to be heterogeneous populations, which potentially allows them to achieve a wide range of responses to environmental changes for the maintenance of CNS homeostasis, a lack of unbiased and high-throughput methods to assess microglia heterogeneity has prevented the study of spatially and temporally distributed microglia subsets. The recent emergence of novel single-cell techniques, freiburger singles as cytometry by time-of-flight mass spectrometry CyTOF and single-cell RNA sequencing, enabled scientists to overcome such limitations and reveal the surprising context-dependent heterogeneity of freiburger singles.
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Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury. Defective cyclophilin A induces TDP proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.
Abstract Interictal epileptiform discharges IEDs are a widely used biomarker in patients with epilepsy but lack specificity. Faculty of Medicine, University of Freiburg.
Robust and efficient single-cell hi-c clustering with approximate k-nearest neighbor graphs
Close freiburger singles search Article. Interictal epileptiform discharges IEDs are a widely used biomarker in patients with epilepsy but lack specificity. Oxford Academic. Article. Download all slides. Deputy Director. Revision received:. In HFO-IEDs, many neurons are moderately activated, and some participate selectively, suggesting that both types of increased firing contribute to highly pathological IEDs.
Volume Interictal spikes with and without high-frequency oscillation have different single-neuron correlates. Armin Brandt.
It has been proposed that there are truly epileptogenic and less pathological or even protective IEDs. Andreas Schulze-Bonhage. Search Menu. Receive exclusive offers and updates from Oxford Academic.
Microglia heterogeneity in the single-cell era
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