The role of microRNAome atures during the longitudinal course of schizophrenia: Biomarkers and pathomechanisms.
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Mission: Integration of molecular biology and epidemiology for modeling ingolstädter models mechanisms of radiation induced pathogenesis. Based on biological processes, the pathogenesis will be modelled over several orders of magnitude, starting from the cell, via the organ to population-at-risk multi-scale modelling. A second area of research is the development and application of measurement techniques for determination of dose distributions in radiation therapy and diagnostics and in the case of unplanned exposure of the general population. Mechanistic Modelling of the development of adenoma and carcinoma in the colon.
Keywords: Ingolstädter models parameter estimation; approximate Bayesian computation; high-performance computing; model-based data integration; multi-scale modeling; statistical inference; tumor spheroids. Abstract Mechanistic understanding of multi-scale biological processes, such as cell proliferation in a changing biological tissue, is readily facilitated by computational models.
Our study demonstrates a proof of principle for robust, data-driven modeling of multi-scale biological systems and the feasibility of multi-scale model parameterization through statistical inference. Mechanistic understanding of multi-scale biological processes, such as cell proliferation in a changing biological tissue, is readily facilitated by computational models.
Publication types Research Support, Non-U. The models capture the hybrid deterministic-stochastic behaviors of 10 5 6 of cells growing in a 3D dynamically changing nutrient environment. Published by Elsevier Inc. All rights reserved.
While tools exist to construct and simulate multi-scale models, the statistical inference of the unknown model parameters remains an open problem.